Psychotropic Agents. IV. Syntheses of β-Phenyl-γ-butyrolactone Derivatives
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概要
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β-Phenyl-γ-butyrolactones (IIIa-j) bearing several substituents on the phenyl ring were synthesized. Deamination of 4-amino-3-(2,4,6-trimethylphenyl) butyric acid (IV) with nitrous acid gave rearranged compounds, β-(2,4,6-trimethylbenzyl)-β-propiolactone (V) and 3-hydroxy-4-(2,4,6-trimethylphenyl) butyric acid (VI) together with the required β-(2,4,6-trimethylphenyl)-γ-butyrolactone (IIIj). Reaction of 2-phenyloxirane derivatives (IXh-j) with sodium diethylmalonate was found to be a convenient method for the preparation of β-phenyl-γ-butyrolactones (IIIh-j) substituted with electron-donating group on the phenyl ring.
- 公益社団法人日本薬学会の論文
- 1981-10-25
著者
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佐藤 誠
Faculty of Pharmaceutical Sciences Toyama Medical and Pharmaceutical University
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佐藤 誠
Research Institute, Daiichi Seiyaku Co., Ltd.,
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小笹山 瑛
Research Institute, Daiichi Seiyaku Co., Ltd.
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内丸 文彦
Research Institute, Daiichi Seiyaku Co., Ltd.
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小笹山 瑛
第一製薬
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内丸 文彦
Research Institute Daiichi Seiyaku Co. Ltd.
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小笹山 瑛
Research Institute Daiichi Seiyaku Co. Ltd.
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