Studies on Antiulcer Agents. II. Antiulcer Properties of N-(1H-Tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides Inhibiting Release of Histamine from Passively Sensitized Rat Peritoneal Mast Cells
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概要
- 論文の詳細を見る
With the aim of applying mast cell-stabilizing agents as antiulcer agents, N-(1H-tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides were synthesized, and initially evaluated pharmacologically for activity in the rat passive cutaneous anaphylaxis test by oral administration. The most active compound 6 was proved to inhibit potently the release of histamine from passively sensitized rat peritoneal mast cells in vitro. When compared with other mast cell-stabilizing agents and an antiulcer agent, compound 6 was found to show excellent gastric mucosal protection and gastric antisecretion activities. Furthermore, compound 6 revealed good activity against acidified aspirin ulcer in rats and water-immersion stress ulcer in rats.
- 社団法人日本薬学会の論文
- 1995-06-15
著者
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上崎 利昭
Research Laboratories Roussel Morishita Co. Ltd.
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嶋村 浩
Research Laboratories, Morishita Pharmaceutical Co., Ltd.
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TANAKA Yasuko
Showa College of Pharmaceutical Sciences
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佐藤 誠
Research Institute, Daiichi Seiyaku Co., Ltd.,
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佐藤 誠
日本ヘキスト・マリオン・ルセル(株)研究開発本部開発研究所滋賀サイト
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Tanaka Y
Osaka University Of Pharmaceutical Science
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寺島 幸司
Research Laboratories, Roussel Morishita Co., Ltd.,
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川瀬 明人
Research Laboratories, Roussel Morishita Co., Ltd.,
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田中 裕二
Research Laboratories, Roussel Morishita Co., Ltd.,
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谷村 テル
Research Laboratories, Roussel Morishita Co., Ltd.,
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石塚 泰博
Research Laboratories, Roussel Morishita Co., Ltd.,
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上西 啓司
Research Laboratories, Roussel Morishita Co., Ltd.,
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木村 伊佐美
Research Laboratories, Roussel Morishita Co., Ltd.,
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Shimamura H
Research Laboratories Roussel Morishita Co. Ltd.
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嶋村 浩
Research Laboratories Roussel Morishita Co. Ltd.
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嶋村 浩
Research Laboratories Morishita Pharmaceutical Co. Ltd.
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Kimura Isami
Research Laboratories Roussel Morishita Co. Ltd.
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田中 裕二
Research Laboratories Roussel Morishita Co. Ltd.
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石塚 泰博
Research Laboratories Roussel Morishita Co. Ltd.
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木村 伊佐美
日本ヘキスト・マリオン・ルセル(株)研究開発本部開発研究所滋賀サイト
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谷村 テル
Research Laboratories Roussel Morishita Co. Ltd.
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上西 啓司
Research Laboratories Roussel Morishita Co. Ltd.
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川瀬 明人
Chugai Pharmaceutical Co. Ltd. Tokyo Jpn
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寺島 幸司
Research Laboratories Roussel Morishita Co. Ltd.
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川瀬 明人
Research Laboratories Roussel Morishita Co. Ltd.
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