Studies on Antiulcer Agents. IV. Antiulcer Effects of 2-Benzylthio-5,6,7,8-tetrahydro-4(3H)-quinazolinones and Related Compounds
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概要
- 論文の詳細を見る
With a view to finding more effective antiulcer agents, a series of 2-benzylthio-5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds were synthesized and evaluated in a histamine-stimulated gastric secretion model. The sodium salt of the 2-(dimethylamino)benzylthio derivative (8) showed gastric mucosal protection and gastric antisecretion activities, and was also effective against experimantal gastric and duodenal ulcers induced by some ulcerogenic agents. Based on a comparison of the antiulcer properties of 8 with those of the lead compounds (1 and 2) and cimetidine, it appears that, for improvement of antiulcer activity, the reduction of gastric acidity is a more important factor than the reduction of gastric volume output or gastric total acid output.
- 社団法人日本薬学会の論文
- 1995-11-15
著者
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上崎 利昭
Research Laboratories Roussel Morishita Co. Ltd.
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嶋村 浩
Research Laboratories, Morishita Pharmaceutical Co., Ltd.
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TANAKA Yasuko
Showa College of Pharmaceutical Sciences
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佐藤 誠
Research Institute, Daiichi Seiyaku Co., Ltd.,
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佐藤 誠
日本ヘキスト・マリオン・ルセル(株)研究開発本部開発研究所滋賀サイト
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Tanaka Y
Osaka University Of Pharmaceutical Science
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寺島 幸司
Research Laboratories, Roussel Morishita Co., Ltd.,
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川瀬 明人
Research Laboratories, Roussel Morishita Co., Ltd.,
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田中 裕二
Research Laboratories, Roussel Morishita Co., Ltd.,
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谷村 テル
Research Laboratories, Roussel Morishita Co., Ltd.,
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石塚 泰博
Research Laboratories, Roussel Morishita Co., Ltd.,
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Shimamura H
Research Laboratories Roussel Morishita Co. Ltd.
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嶋村 浩
Research Laboratories Roussel Morishita Co. Ltd.
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嶋村 浩
Research Laboratories Morishita Pharmaceutical Co. Ltd.
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田中 裕二
Research Laboratories Roussel Morishita Co. Ltd.
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石塚 泰博
Research Laboratories Roussel Morishita Co. Ltd.
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谷村 テル
Research Laboratories Roussel Morishita Co. Ltd.
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川瀬 明人
Chugai Pharmaceutical Co. Ltd. Tokyo Jpn
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寺島 幸司
Research Laboratories Roussel Morishita Co. Ltd.
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川瀬 明人
Research Laboratories Roussel Morishita Co. Ltd.
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