Psychotropic Agents. V. Synthesis of 1,3-Diphenyl-4-(4-substituted piperidinyl)-1-butanones and Related Compounds
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概要
- 論文の詳細を見る
A series of 1,3-diphenyl-1-butanone derivatives (11-14) was synthesized as part of a search for new psychotropic agents. In the reaction of 4-chloro-1,3-diphenyl-1-butanones (8a, d) with piperidine derivatives (10,15), rearranged products (16-18) were obtained together with 1,3-diphenyl-1-butanone derivatives (11,14,20). A reaction mechanism involving the cyclization of 8a, d to cyclopropane derivatives (22a, d) and subsequent addition reaction with piperidine derivatives (10,15) to 22a, d is proposed.
- 公益社団法人日本薬学会の論文
- 1981-11-25
著者
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佐藤 誠
Faculty of Pharmaceutical Sciences Toyama Medical and Pharmaceutical University
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佐藤 誠
Research Institute, Daiichi Seiyaku Co., Ltd.,
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内丸 文彦
Research Institute, Daiichi Seiyaku Co., Ltd.
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内丸 文彦
Research Institute Daiichi Seiyaku Co. Ltd.
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