Cyclic Guanidines. XI. Hydroxy and Aminoimidazo [2,1-b]-quinazolines and Related Compounds
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概要
- 論文の詳細を見る
The Phenyl-substituted 1-methyl tricyclic guanidine (1) having an imidazo- or pyrimido-[2,1-b] quinazoline ring was easily oxidized at the methine group adjacent to the aromatic rings to give the 5-hydroxy- or 6-hydroxy derivative (2), respectively. Reaction of 2-aminobenzophenone with 2-chloro-2-imidazoline gave the 1-unsubstituted 5-hydroxy-imidazo [2,1-b] quinazoline derivative (5). The structures of compounds 2 and 5 are discussed. 1-Hydroxy- (13) and 1-amino tricyclic guanidines (16) were prepared by the reaction of 2-chloro-3-(2-chloroethyl)-4-phenyl-3,4-dihydroquinazoline with hydroxylamine and hydrazine, respectively. Compounds 2,5 and 13 showed hypoglycemic and platelet aggregation inhibitory activity.
- 公益社団法人日本薬学会の論文
- 1980-07-25
著者
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小笹山 瑛
Research Institute, Daiichi Seiyaku Co., Ltd.
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石川 文義
Research Institute, Daiichi Seiyaku Co., Ltd.
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東 邦夫
Research Institute Daiichi Seiyaku Co. Ltd.
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石川 文義
Research Institute Daiichi Seiyaku Co. Ltd.
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小笹山 瑛
第一製薬
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小笹山 瑛
Research Institute Daiichi Seiyaku Co. Ltd.
関連論文
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- Cyclic Guanidines. VI. Synthesis of Hypoglycemic Tricyclic Guanidines
- Cyclic Guanidines. V. Synthesis of Hypoglycemic 2,2- and 3,3-Diphenylimidazo [1,2-a] [1,3]-diazacycloalkane Derivatives
- Cyclic Guanidines. IV. Synthesis of Hypoglycemic N-Benzhydryl Bicyclic Guanidines
- Cyclic Guanidines. III. Synthesis of Hypoglycemic 2-Benzhydrylimino-1,3-diazacycloalkanes
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- Cyclic Guanidines. XV. Synthesis and Biological Activities of (Substituted phenyl)-imidazo [1,2-a] imidazole Derivatives
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- Cyclic Guanidines. XI. Hydroxy and Aminoimidazo [2,1-b]-quinazolines and Related Compounds
- Cyclic Guanidines. VII. Structure-Activity Relationships of Hypoglycemic Cyclic Guanidines
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- Cyclic Guanidines. I. Synthesis of Hypoglycemic 1-Substituted 2-Imino-1,3-diazacycloalkanes
- Studies on Pyrazine Derivatives. IV. Coupling Constants and Chemical Shifts in Disubstituted Pyrazines
- Syntheses of 1-Pyrazylpyridinium Salts, and Pyrido [1', 2' : 1,2] imidazo-[4,5-b] pyrazines, a New Type of Heterocyclic Compounds
- Studies on Pyrazine Derivatives. II. Synthesis, Reactions, and Spectra of Pyrazine N-Oxide Derivatives
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- Interactions between Synthetic Nucleotide Analogs and Snake Venom 5'-Nucleotidase
- A New and Convenient Synthesis of 1-O-Acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose from Guanosine ; Some Observations on Solvolysis of 2', 3', 5'-Tri-O-benzoylguanosine
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- Studies on Coenzyme Analogs. IX. Synthesis of 6-Alkylamino-9-β-D-ribofuranosylpurine 5'-Monophosphate.