Thromboxane A_2 Synthetase Inhibitors. I. : Syntheses and Activities of Various N-Heteroaromatic Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Basic N-heteroaromatic derivatives (1,2,4-triazole, thiazole and pyrimidine derivatives) having a 2-[4-(carboxy)phenoxy]ethyl moiety or a 4-[2-(carboxy)vinyl]benzyl moiety were prepared, and evaluated for ability to inhibit thromboxane A_2 (TXA_2) synthesis. Among the compounds prepared in this study, the 5-substituted thiazole derivatives 14d, 27 and 28 were more potent inhibitors of TXA_2 production than the corresponding imidazole derivatives, and the 1-substituted 1H-1,2,4-triazole derivatives 14a and 15a were almost as potent as the corresponding imidazole derivatives.
- 公益社団法人日本薬学会の論文
- 1988-08-25
著者
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渡辺 好文
Daiichi Pharmaceutical Co. Ltd. Research Institute
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金尾 宗史
Daiichi Pharmaceutical Co., Ltd.,
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菅野 英幸
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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木村 陽一
Daiichi Seiyaku Co., Ltd., Research Institute
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菅野 英幸
Daiichi Seiyaku Co., Ltd., Research Institute
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久保 英夫
Daiichi Seiyaku Co., Ltd., Research Institute
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芦田 伸一郎
Daiichi Seiyaku Co., Ltd., Research Institute
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久保 英夫
Daiichi Seiyaku Co. Ltd. Research Institute
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木村 陽一
Daiichi Seiyaku Co. Ltd. Research Institute
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金尾 宗史
Daiichi Pharmaceutical Co. Ltd.
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芦田 伸一郎
Daiichi Seiyaku Co. Ltd. Research Institute
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