Aryloxyacetic Acid Diuretics with Uricosuric Activity. II. Substituted [(4-Oxo-4H-1-benzopyran-7-yl)oxy]acetic Acids and the Related Compounds
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概要
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Di- and tri-substituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids, and 4-oxo-3-phenyl-4H-furo[2,3-h]-[1]benzopyran-8-carboxylic acid were synthesized and tested for natriuretic acid uricosuric activities. Among the compounds tested, 3,5-disubstituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids (6c-f, h, n and x) showed potent natriuretic acid uricosuric activities, whereas 4-oxo-3-phenyl-4H-furo[2,3-h][1]benzopyran-8-carboxylic acid (6dd) possessed only potent natriuretic activity. The structure-activity relationships are also discussed.
- 社団法人日本薬学会の論文
- 1991-10-25
著者
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田中 真
Research Institute Daiichi Pharmaceutical Co. Ltd.
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北川 正之
Research Institute, Daiichi Pharmaceutical Co., Ltd.,
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山本 健二郎
Research Institute, Daiichi Pharmaceutical Co., Ltd.,
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片倉 晋一
Research Institute, Daiichi Pharmaceutical Co., Ltd.,
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菅野 英幸
Research Institute, Daiichi Pharmaceutical Co., Ltd.,
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山田 晃司
Research Institute, Daiichi Pharmaceutical Co., Ltd.,
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永原 孝恭
Research Institute, Daiichi Pharmaceutical Co., Ltd.,
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山田 晃司
Daiichi Pharmaceutical Co., Ltd.,
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菅野 英幸
Exploratory Research Laboratories Iii Daiichi Pharmaceutical Co. Ltd.
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山田 晃司
Daiichi Pharmaceutical Co. Ltd.
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片倉 晋一
Research Institute Daiichi Pharmaceutical Co. Ltd.
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山本 健二郎
Research Institute Daiichi Pharmaceutical Co. Ltd.
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北川 正之
Research Institute Daiichi Pharmaceutical Co. Ltd.
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永原 孝恭
Research Institute Daiichi Pharmaceutical Co. Ltd.
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