Aryloxy Acetic Acid Diuretics with Uricosuric Activity. I. Polycyclic Aryloxy Acetic Acids

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概要

• 論文の詳細を見る

• In order to obtain lead compounds for uricosuric diuretics, various polycyclic aryloxy acetic acids [isoindole derivative (7), quinazoline derivative (15), benzopyran derivative (20), xanthone derivative (24), benzofuran derivative (30) and indene derivative (36)] were prepared. These compounds were evaluated for diuretic activity in rats, uricosuric activity in rats and antihypertensive activity in 11-deoxycorticosterone acetate (DOCA)/salt hypertensive rats. Among the compounds, 20 showed potent diuretic, uricosuric and moderate antihypertensive activities. Therefore, we selected 20 as a lead compound for development of new uricosuric diuretics.

• 社団法人日本薬学会の論文
• 1991-09-25

著者

• 田中 真

  Research Institute Daiichi Pharmaceutical Co. Ltd.

• 北川 正之

  Research Institute, Daiichi Pharmaceutical Co., Ltd.,

• 三村 哲哉

  Research Institute, Daiichi Pharmaceutical Co., Ltd.,

• 三村 哲哉

  Research Institute Daiichi Pharmaceutical Co. Ltd.

• 北川 正之

  Research Institute Daiichi Pharmaceutical Co. Ltd.

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