Effect of Magnesium Lithospermate B on Urinary Excretion of Arachidonate Metabolites in Rats with Renal Failure

概要

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The effect of magnesium lithospermate B isolated from Salviae miltiorrhizae Radix on excretion of urinary arachidonate metabolites was examined in both normal rats and those given adenine. Urinary excretion of prostaglandin E_2 (PGE_2) and 6-keto-prostaglandin F_<1α> (6-keto-PGF_<1α>) decreased while urinary thromboxane B_2 (TXB_2) excretion increased markedly with the progression of renal failure. Rats administered magnesium lithospermate B showed an increase of urinary PGE_2 excretion at the 6th and 12th days. Excretion of 6-keto-PGF_<1α> also showed a significant increase on the 6th and 12th days in rats with renal failure induced by the administration of adenine. However, these effects were lower than the corresponding values in normal rats. In addition, urinary PGE_2 and 6-keto-PGF_<1α> excretions showed no appreciable difference in rats that exhibited progressive renal failure with continuation of the adenine administration period, as shown on the 18th and 24th days. There were no significant changes in TXB_2 excretion between the control and magnesium lithospermate B-treated groups throughout the experimental period.
社団法人日本薬学会の論文
1989-10-25