Studies on Prodrugs. VIII. : Preparation and Characterization of (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Esters of Sulbactam and Its Analogs
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概要
- 論文の詳細を見る
Several (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl esters of β-lactamase inhibitors were prepared and evaluated for oral absorbability. Sulbactam (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester (5a) was found to prodece a 5-fold higher serum level of sulbactam than sulbactam itself after oral administration to mice. The diester (15), in which ampicilling is bonded to the 5-methyl group of the above sulbactam ester (5a), was also prepared, but this diester (15) did not produce high serum levels of ampicillin and sulbactam after oral administration to mice.
- 公益社団法人日本薬学会の論文
- 1988-01-25
著者
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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池田 昇司
Pharmaceuticals Reseach Center Kanebo Ltd.
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武部 靖
Pharmaceuticals Reseach Center Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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平山 良一
Pharmaceuticals Reseach Center Kanebo Ltd.
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坂本 文夫
Pharmaceuticals Reseach Center, Kanebo Ltd.,
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外村 幹夫
Pharmaceuticals Reseach Center, Kanebo Ltd.,
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坂本 文夫
Pharmaceuticals Research Center Kanebo Co. Ltd.
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外村 幹夫
Pharmaceuticals Reseach Center Kanebo Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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