Benzylpiperazine Derivatives. I. Syntheses and Biological Activities of 1-(2,3,4-Trimethoxybenzyl)piperazine Derivatives(Medicinal Chemistry,Chemical)
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概要
- 論文の詳細を見る
A series of 1-(2,3,4-trimethoxybenzyl)piperazine (trimetazidine) derivatives were prepared and tested for cerebral vasodilating activity. Almost all the compounds possess stronger activity than trimetazidine and among them, the γ-amino tertiary alcohols 6e-j exhibit potent cerebral vasodilating activities which are superior to those of cinnarizine and papaverine. Moreover, these compounds show a selective vasodilating effect on vertebral arteries.
- 公益社団法人日本薬学会の論文
- 1987-07-25
著者
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大高 博
Pharmaceuticals Research Center, Kanebo Ltd.,
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大高 博
New Drug Research Laboratories Kanebo Ltd.
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伊藤 敬三
鐘紡
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伊藤 敬三
Pharmaceuticals Research Center Kanebo Ltd.
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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金沢 稔郎
Pharmaceuticals Research Center, Kanebo Ltd.
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三宅 和夫
Pharmaceuticals Research Center, Kanebo Ltd.
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伊藤 敬三
Pharmaceutical Research Center Kanebo Co. Ltd.
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三宅 和夫
Pharmaceuticals Research Center Kanebo Ltd.
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金沢 稔郎
Pharmaceuticals Research Center Kanebo Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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