Potential Nootropic Agents, 4-Alkoxy-2-(1-piperazinyl)quinazoline Derivatives

スポンサーリンク

概要

• 論文の詳細を見る

• A series of 4-alkoxy-2-(1-piperazinyl)quinazoline derivatives was synthesized and evaluated for its ability to reverse a scopolamine-induced learned impairment in a one-trial passive avoidance task (antiamnestic activity). 2-(4-Allyl-1-piperazinyl)-4-pentyloxyquinazoline (4) showed more potent antiamnestic activity than such reference compounds as aniracetam, idebenone and bifemelane at a wide dose range (1-30 mg/kg)). Compound 4 also exhibited potent anticonvulsive and antihypoxic activities, and was selected as the most promising nootropic candidate agent.

• 公益社団法人日本薬学会の論文
• 1991-02-25

著者

• 原 英彰

  鐘紡(株)薬品開発第一研究所薬理研究部

• 原 英彰

  Pharmaceuticals Research Center Kanebo Ltd.

• 洲加本 孝幸

  鐘紡(株)薬品開発第一研究所薬理研究部

• 堀 学

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 家村 隆一

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 洲加本 孝幸

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 大高 博

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 大高 博

  New Drug Research Laboratories Kanebo Ltd.

• 伊藤 敬三

  鐘紡

• 伊藤 敬三

  Pharmaceuticals Research Center Kanebo Ltd.

• 堀 学

  New Drug Research Laboratories, Kanebo Ltd.,

• 堀 学

  New Drug Research Laboratories Kanebo Ltd.

• 家村 隆一

  Pharmaceuticals Research Center Kanebo Ltd.

• 伊藤 敬三

  Pharmaceutical Research Center Kanebo Co. Ltd.

関連論文

• ゲンノショウコエキス配合止瀉剤の収斂作用および空腸粘膜の短絡電流に対する作用
• Novel 4-Substituted 2-Piperazinylquinazolines as Potent Anticonvulsive and Antihypoxic Agents
• ラウリン酸ナトリウム誘発モルモット末梢動脈閉塞モデルに対する抗血小板薬 pamicogrel の作用
• ロメリジンの抗片頭痛作用
• 新規抗血小板薬 Ethyl 2-[4, 5-bis(4-methoxyphenyl)thiazol-2-yl]pyrrol-1-ylacetate (KBT-3022) の一般薬理作用 (2) 呼吸・循環器系, 消化器系および平滑筋に及ぼす影響
• 数種漢方処方の胃機能に対する薬理学的研究-1-エタノ-ルおよびアスピリンによる胃粘膜関門の破綻に対する黄連解毒湯,三黄瀉心湯,安中散および大柴胡湯の作用
• Synthesis and Analgesic Activity of C-Terminal Fragment Peptides of Cholecystokinin(Medicinal Chemistry,Chemical)
• Chemical Transformation of Terpenoids. I. Syntheses of (3S)-1-Vinyl-, (3S)-1-Hydroxypropenyl-, and (3S)-1-Epoxyethyl-1,2,2-trimethylcyclopentane Derivatives from d-Camphor via d-Camphoric Acid
• 18 タキサン型ジテルペンの合成研究 その1
• 9カ月齢の卵巣摘出ラットにおける KB-889 (Tibolone) 3カ月間投与の作用
• マウスにおける加味帰脾湯の抗侵害受容作用
• Marine Natural Products. XVIII. : Four Lanostane-Type Triterpene Oligoglycosides, Bivittosides A, B, C, and D, from the Okinawan Sea Cucumber Bohadschia bivittata MITSUKURI
• Benzylpiperazine Derivatives. X. : Syntheses ans Structure-Antiulcer Activity Relationship of 1-Benzyl-4-piperazineacetic Acid Esters
• Benzylpiperazine Derivatives. VIII. : Syntheses, Antiulcer and Cytoprotective Activities of 1-(Aminocarbonylalkyl)-4-benzylpiperazine Derivatives and Related Compounds
• Studies on Iridoid-Related Compounds. IV. : Antitumor Activity of Iridoid Aglycones
• Design and Syntheses of a Series of Novel Serotonin_3 Antagonists
• Effects of a 2-Substituent on the Ratio of N- and O-Alkylation of 4(3H)-Quinazolinones
• Potential Nootropic Agents, 4-Alkoxy-2-(1-piperazinyl)quinazoline Derivatives
• Novel 4-Phenoxy-2-(1-piperazinyl)quinazolines as Potent Anticonvulsive and Antihypoxic Agents
• Benzylpiperazine Derivatives. XI. : Synthesis of Compounds Related to the Metabolites of 1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine Dihydrochloride (KB-2796)
• Bioisosteric Transformation of H_1-Antihistaminic Benzimidazole Derivatives
• Quantitative Structure-Activity Relationships of H_1-Antihistaminic Benzimidazole Derivatives
• Syntheses of the Metabolites of 1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H-benzimidazole Difumarate (KG-2413) and Related Compounds
• Benzylpiperazine Derivatives. IX. : Structure-Antiulcer Activity Studies of 1-(Aminocarbonylalkyl)-4-benzylpiperazine Derivatives by the Adaptive Least-Squares Method
• Benzylpiperazine Derivatives. VII. Studies on the Role of the Nitrogen Atom in the Cerebral Vasodilating Activity of 1-Benzyl-4-diphenyl-methylpiperazine Derivatives(Medicinal Chemistry,Chemical)
• Benzylpiperazine Derivatives. VI. Design and Syntheses of Vinylogs of 1-Benzyl-4-diphenylmethylpiperazine Derivatives and Their Cerebral Vasodilating Activities(Medicinal Chemistry,Chemical)
• Benzylpiperazine Derivatives. V. Quantitative Structure-Activity Relationships of 1-Benzyl-4-diphenylmethylpiperazine Derivatives for Cerebral Vasodilating Activity(Medicinal Chemistry,Chemical)
• Benzylpiperazine Derivatives. III. Quantitative Structure-Cerebral Vasodilating Activity Relationships of 1-Benzyl-4-(3-hydroxy-3-phenylpentyl)piperazine Derivatives(Medicinal Chemistry,Chemical)
• Benzylpiperazine Derivatives. II. Syntheses and Cerebral Vasodilating Activities of 1-[(3-Alkyl-3-hydroxy-3-phenyl)propyl]-4-benzylpiperazine Derivatives(Medicinal Chemistry,Chemical)
• Benzylpiperazine Derivatives. I. Syntheses and Biological Activities of 1-(2,3,4-Trimethoxybenzyl)piperazine Derivatives(Medicinal Chemistry,Chemical)
• Antibacterial Activity of a New Tetracyclic Quinolone, No, 5290,against Norfloxacin- and Ciprofloxacin-Resistant Strains of Staphylococcus aureus
• Synthesis and Effect on Gastric Secretion of Several Di- or Tripeptides Related to Proglumide
• Synthesis of N-Acyl-γ-D-glutamyl Peptide Derivatives Containing a C-Terminal Small Fragment of Cholecystokinin and Their Effects on Gastric Secretion
• Synthesis and Analgesic Activity of Cholecystokinin-Heptapeptide Analogs with N-Terminal Substitution
• Synthesis of Five Cholecystokinin-like Peptides and Determination of Their Analgesic Effects
• KB-1043ならびに数種抗炎症薬のProstaglandinおよびSRS-A生合成に対する作用
• 新しいベンゾジアゼピン系化合物,7-Chloro-1-cyclopropylmetyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one (KB-509)の抗潰瘍作用
• 新規抗血小板薬 Ethyl 2-[4, 5-bis(4-methoxyphenyl)thiazol-2-yl]pyrrol-1-ylacetate (KBT-3022) の一般薬理作用 (3) 血液, 尿排泄およびその他に及ぼす影響
• 新規抗血小板薬 Ethyl 2-[4, 5-bis(4-methoxyphenyl)thiazol-2-yl]pyrrol-1-ylacetate (KBT-3022) の一般薬理作用 (1) 中枢および自律神経系に及ぼす影響
• Marine Natural Products. XXVII. Distribution of Lanostane-Type Triterpene Oligoglycosides in Ten Kinds of Okinawan Sea Cucumbers
• 古典的QSARを活用した新しい骨格構造をもつ虚血性心疾患治療薬の創製 (特集 創薬研究とコンピューター科学(Part2))
• Structures of Four New Triterpenoidal Oligoglycosides, Bivittoside A, B, C, and D, from the Sea Cucumber Bohadschia bivittata MITSUKURI
• 7-Chloro-1-cyclopropylmethyl-1, 3-dihydro-5-(2-fluorophenyl)-2H-1, 4-benzodiazepin-2-one(KB-509)の中枢および一般薬理作用
• 新規Ca2+チャネル遮断薬KB-2796のセロトニン受容体結合と抗セロトニン作用
• 抗うつ薬 Trazodone とその主要代謝物の脳内モノアミン動態に及ぼす作用
• KB-1043ならびに数種抗炎症薬のProstaglandinおよびSRS-A生合成に対する作用
• 新しいベンゾジアゼピン系化合物，7-Chloro-1-cyclopropylmetyl-1，3-dihydro-5-(2-fluorophenyl)-2H-1，4-benzodiazepin-2-one(KB-509)の抗潰瘍作用

もっと見る 閉じる

スポンサーリンク