Benzylpiperazine Derivatives. IX. : Structure-Antiulcer Activity Studies of 1-(Aminocarbonylalkyl)-4-benzylpiperazine Derivatives by the Adaptive Least-Squares Method
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概要
- 論文の詳細を見る
Quantiative structure-antiulcer activity relationships of 1-(aminocarbonylalkyl)-4-benzyl-piperazine derivatives (I) were analyzed by using the adaptive least-squares (ALS) technique.Discriminant functions show that (1) a bulky amide moiety is disadvantageous, (2) a small number of methylene groups between carbonyl and piperazine is favorable, (3) a substituent which has a large B_1 value (or B_2 value when the substituent is forced to be in the in-plane conformation) with low lipophilicity at the 3 and/or 4 position of the benzyl moiety is favorable for antiulcer activity with low acute toxicity.
- 公益社団法人日本薬学会の論文
- 1988-10-25
著者
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大高 博
Pharmaceuticals Research Center, Kanebo Ltd.,
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大高 博
New Drug Research Laboratories Kanebo Ltd.
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吉田 健二
Pharmaceuticals Research Center Kanebo Ltd.
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鈴木 健司
New Drug Research Laboratories Kanebo Ltd.
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鈴木 健司
Pharmaceuticals Research Center, Kanebo Ltd.,
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