Effects of a 2-Substituent on the Ratio of N- and O-Alkylation of 4(3H)-Quinazolinones
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概要
- 論文の詳細を見る
Alkylation of 4(3H)-quinazolinones with 1-iodopentane in the presence of sodium hydride gave a mixture of 3-pentyl-4(3H)-quinazolinones (2) and 4-pentyloxyquinazolines (3). The ratio of O-alkyl/N-alkyl products varied according to the 2-substituents of the quinazoline ring. Multiple regression analyses revealed that the ratio was determined by a steric factor (width parameter of B) and an electronic factor (in terms of Hammett's σ_p) of the 2-substituent. It was found to be the case in the reported alkylation of 4(3H)-quinazolinones with propargyl bromide.
- 公益社団法人日本薬学会の論文
- 1993-06-15
著者
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大高 博
New Drug Research Laboratories Kanebo Ltd.
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堀 学
New Drug Research Laboratories, Kanebo Ltd.,
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堀 学
New Drug Research Laboratories Kanebo Ltd.
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