Benzylpiperazine Derivatives. VI. Design and Syntheses of Vinylogs of 1-Benzyl-4-diphenylmethylpiperazine Derivatives and Their Cerebral Vasodilating Activities(Medicinal Chemistry,Chemical)
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概要
- 論文の詳細を見る
As a lead development based on the previous quantitative structure-activity relationship (QSAR) results on cerebral vasodilating activities of 1-benzyl-4-diphenylmethylpiperazines, 1-cinnamyl-4-diphenylmethylpiperazines having electron-donating groups on the cinnamyl moiety were designed. Two methods of synthesis were developed. As expected from the QSAR results, these compounds exhibited stronger potency and longer-lasting effect than cinnarizine and flunarizine.
- 公益社団法人日本薬学会の論文
- 1987-10-25
著者
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大高 博
Pharmaceuticals Research Center, Kanebo Ltd.,
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大高 博
New Drug Research Laboratories Kanebo Ltd.
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伊藤 敬三
鐘紡
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伊藤 敬三
Pharmaceuticals Research Center Kanebo Ltd.
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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金沢 稔郎
Pharmaceuticals Research Center, Kanebo Ltd.
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伊藤 敬三
Pharmaceutical Research Center Kanebo Co. Ltd.
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金沢 稔郎
Pharmaceuticals Research Center Kanebo Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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