Novel Disease-Modifying Antirheumatic Drugs. I. Sythesis and Antiarthritic Activity of 2-(4-Methylphenyl)benzothiazoles
スポンサーリンク
概要
- 論文の詳細を見る
A series of 2-(4-methylphenyl)benzothiazoles was synthesized and evaluated using an adjuvant-induced arthritic rat model. This calss of desired compounds affecting the immune response was found using hemagglutination assay.4-Acetoxy-2-(4-methylphenyl)benzothiazole (7m), KB-2683,was most potent in the adjuvant-induced arthritic rat model and selected for further evalution. In contrast to nonsteroidal antiinflammatory drugs, compound 7m showed no antiinflammatory or analgesic activities. It did, however, show an immunomodulatory activity in enhanced delayed type hypersensitivity.
- 公益社団法人日本薬学会の論文
- 1992-09-25
著者
-
塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
-
大橋 正美
New Drug Research Laboratories, Kanebo, Ltd.,
-
大橋 正美
New Drug Research Laboratories Kanebo Ltd.
-
今村 淳資
New Drug Research Laboratories Kanebo Ltd.
-
斎藤 忠之
New Drug Research Laboratories Kanebo Ltd.
-
YOSHINO Kohichiro
New Drug Discovery Research Laboratory, Kanebo Ltd.,
-
堀 徳之
New Drug research Laboratories, Kanebo, Ltd.
-
Yoshino Kohichiro
New Drug Research Laboratories Kanebo Ltd.
-
堀 徳之
New Drug Research Laboratories Kanebo Ltd.
関連論文
- Synthesis and Analgesic Activity of C-Terminal Fragment Peptides of Cholecystokinin(Medicinal Chemistry,Chemical)
- Azabicycloalkanes as Analgetics. I. Synthesis of 1-Phenyl-6-azabicyclo [3,2,1] octane Derivatives
- Azabicycloalkanes as Analgetics. IV. 4-Phenyl-2-azabicyclo [2,2,1] heptanes
- Benzylpiperazine Derivatives. VII. Studies on the Role of the Nitrogen Atom in the Cerebral Vasodilating Activity of 1-Benzyl-4-diphenyl-methylpiperazine Derivatives(Medicinal Chemistry,Chemical)
- Benzylpiperazine Derivatives. VI. Design and Syntheses of Vinylogs of 1-Benzyl-4-diphenylmethylpiperazine Derivatives and Their Cerebral Vasodilating Activities(Medicinal Chemistry,Chemical)
- Benzylpiperazine Derivatives. V. Quantitative Structure-Activity Relationships of 1-Benzyl-4-diphenylmethylpiperazine Derivatives for Cerebral Vasodilating Activity(Medicinal Chemistry,Chemical)
- Benzylpiperazine Derivatives. III. Quantitative Structure-Cerebral Vasodilating Activity Relationships of 1-Benzyl-4-(3-hydroxy-3-phenylpentyl)piperazine Derivatives(Medicinal Chemistry,Chemical)
- Benzylpiperazine Derivatives. I. Syntheses and Biological Activities of 1-(2,3,4-Trimethoxybenzyl)piperazine Derivatives(Medicinal Chemistry,Chemical)
- Antibacterial Activity of a New Tetracyclic Quinolone, No, 5290,against Norfloxacin- and Ciprofloxacin-Resistant Strains of Staphylococcus aureus
- Synthesis and Effect on Gastric Secretion of Several Di- or Tripeptides Related to Proglumide
- Synthesis of N-Acyl-γ-D-glutamyl Peptide Derivatives Containing a C-Terminal Small Fragment of Cholecystokinin and Their Effects on Gastric Secretion
- Synthesis and Analgesic Activity of Cholecystokinin-Heptapeptide Analogs with N-Terminal Substitution
- Synthesis of Five Cholecystokinin-like Peptides and Determination of Their Analgesic Effects
- A Convenient and Practical Preparation of 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
- Studies on Prodrugs. VIII. : Preparation and Characterization of (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Esters of Sulbactam and Its Analogs
- Studies on Prodrugs. VI. Preparation and Characterization of (5-Substituted 2-Oxo-1,3-dioxol-4-yl)methyl Esters of Mecillinam(Medicinal Chemistry,Chemical)
- Azabicycloalkanes as Analgetics. II. An Improved Synthesis of 1-Phenyl-6-azabicyclo [3,2,1] octane Derivatives
- Synthesis and Platelet Aggregation Inhibitory Activity of Diphenylazole Derivatives. I. Thiazole and Imidazole Derivatives
- Organic Phosphorus Compounds. IV : Asymmetric 4-(Benzothiazol-2-yl)benxylphosphonates as Potent Calcium Antagonistic Vasodilators
- Synthesis and Structure-Activity Relationships of Thienylcyanoguanidine Derivatives as Potassium Channel Openers
- Synthesis and Structure-Activity Relationships of Novel phenylcyanoguanidine Derivatives as Potassium Channel Openers
- Synthesis of Sodium Rifamycin S-3-Sulfonate and Its Reaction with Amines
- 2-Oxo-1,3-dioxols as Specific Substrates for Measurement of Arylesterase Activity
- Studies on Prodrugs. IV. Preparation and Characterization of N-(5-Substituted 2-oxo-1,3-dioxol-4-yl) methyl Norfloxacin
- Studies on Prodrugs. III. A Convenient and Practical Preparation of Ampicillin Prodrugs
- Studies on Prodrugs. II. Preparation and Characterization of (5-Substituted 2-Oxo-1,3-dioxolen-4-yl) methyl Esters of Ampicillin
- Studies on Prodrugs. I. Preparation and Characterization of Acyloxyallylester of Ampicillin
- A Novel Synthetic Method for Penicillanic Acid Derivatives by Electroreduction
- Novel Disease-Modifying Antirheumatic Drugs. I. Sythesis and Antiarthritic Activity of 2-(4-Methylphenyl)benzothiazoles
- リファマイシンに関する研究
- ^1H-and ^C-Nuclear Magnetic Resonance Spectra of Rifampicin and 3-[(Dimethylhydrazono)methyl]rifamycin SV
- Chemical Modification of the Amide Group of Rifamycin S
- Reaction of 3-Formylrifamycin S with Secondary Amines
- Reaction of 3-Formylrifamycin SV with Formalin in Combination with Primary Alkylamines