Studies on Prodrugs. III. A Convenient and Practical Preparation of Ampicillin Prodrugs
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概要
- 論文の詳細を見る
In order to prepare ampicillin prodrugs conveniently for practical use, a new synthetic method for 6β-aminopenicillanic acid (6-APA) esters as key intermediates of various ampicillin prodrugs has been developed. Acylation of 6-APA esters to ampicillin esters was achieved in good yields by using phenylglycyl chloride hydrochloride in dichloromethane in the presence of sodium bicarbonate and amide, or ammonium bicarbonate alone. KBT-1585,bacampicillin, talampicillin and pivampicillin have been obtained in good yields by this procedure.
- 公益社団法人日本薬学会の論文
- 1984-11-25
著者
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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池田 昇司
Pharmaceuticals Research Center Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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坂本 文夫
Pharmaceuticals Reseach Center, Kanebo Ltd.,
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森山 勝
Pharmaceuticals Research Center, Kanebo Co., Ltd.
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坂本 文夫
Pharmaceuticals Research Center Kanebo Co. Ltd.
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近藤 裕郷
Pharmaceuticals Research Center Kanebo Co. Ltd.
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森山 勝
Pharmaceuticals Research Center Kanebo Co. Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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