Synthesis of N-Acyl-γ-D-glutamyl Peptide Derivatives Containing a C-Terminal Small Fragment of Cholecystokinin and Their Effects on Gastric Secretion
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概要
- 論文の詳細を見る
N-Acyl-γ-D-glutamyl peptide derivatives containing a C-terminal small fragment of cholecystokinin were prepared and their effects on gastric secretion were investigated. PhCO-D-Glu(Phe-NH_2)-NPr_2 and PhCO-D-Glu(Asp-Phe-NH_2)-NPr_2 inhibited gastric secretion, while PhCO-D-Glu(Met-Asp-Phe-NH_2)-NPr_2 and PhCO-D-Glu(Trp-Met-Asp-Phe-NH_2)-NPr_2 stimulated gastric secretion. The substitution of the acyl function at the N-terminal of PhCO-D-Glu(Phe-NH_2)-NPr_2 affected the activity. Z-D-Glu(Phe-NH_2)-NPr_2,4-chlorobenzoyl-D-Glu-(Phe-NH_2)-NPr_2 and isonicotinoyl-D-Glu(Phe-NH_2)-NPr_2 were found to have more potent inhibitory activity against gastric secretion than proglumide (PhCO-DL-Glu-NPr_2).
- 公益社団法人日本薬学会の論文
- 1988-09-25
著者
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伊藤 敬三
鐘紡
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伊藤 敬三
Pharmaceuticals Research Center Kanebo Ltd.
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井内 浤二
Pharmaceuticals Research Center, Kanebo Ltd.
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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井内 浤二
Pharmaceuticals Reseach Center Kanebo Ltd.
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伊藤 敬三
Pharmaceutical Research Center Kanebo Co. Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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