Studies on Prodrugs. I. Preparation and Characterization of Acyloxyallylester of Ampicillin
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概要
- 論文の詳細を見る
In order to investigate a new type of promoiety for ampicillin prodrugs, acyloxyallyl esters were prepared and their oral absorbabilities, stabilities and hydrolyzabilities to parent ampicillin were studied. As starting materials for (3-phthalidylidene)ethyl esters, ethylidenephthalide and its derivatives were regiospecifically prepared by a new method using the Wittig reaction. (3-Phthalidylidene)ethyl esters (14a-c) given orally were well absorbed, but (thiophthalidylidene)ethyl ester (14d) and (isocoumarin-4-yl)methyl ester (14e) were poorly absorbed.
- 公益社団法人日本薬学会の論文
- 1983-08-25
著者
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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池田 昇司
Pharmaceuticals Reseach Center Kanebo Ltd.
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池田 昇司
Pharmaceuticals Research Center Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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坂本 文夫
Pharmaceuticals Research Center Kanebo Co. Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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