Reaction of 3-Formylrifamycin S with Secondary Amines

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概要

• 論文の詳細を見る

• 3-Formylrifamycin S (9) was found to react with secondary aliphatic amines to give 2,3-dihydropyrimido [4,5-b] rifamycin derivatives 4,in which the 2'-position was substituted with an alkyl group. When 7-, 8-, and 9-membered alicyclic amines were used, 2,3-dihydropyrimido [4,5-b] rifamycin derivatives 5,in which the 1'-and 2'-position were linked with a methylene chain, were obtained. The configuration of the 2'-position in 4 and 5 is discussed. The mechanism of formation of 4 and 5 is also discussed.

• 公益社団法人日本薬学会の論文
• 1984-11-25

著者

• 塚本 悟郎

  Pharmaceuticals Research Center, Kanebo Ltd.

• 塚本 悟郎

  New Drug Research Laboratories Kanebo Ltd.

• 相川 法男

  Pharmaceuticals Research Center, Kanebo, Ltd.

• 田口 雅裕

  Pharmaceuticals Research Center Kanebo Co. Ltd.

• 相川 法男

  Pharmaceuticals Research Center

• 塚本 悟郎

  Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.

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