A Convenient and Practical Preparation of 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
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概要
- 論文の詳細を見る
A new-synthetic method for 4-chloromethyl-5-methyl-1,3-dioxol-2-one (1c), which is useful for preparing prodrugs, has been developed. Ene-chlorination of 4,5-dimethyl-1,3-dioxol-2-one (2) with chlorine or sulfuryl chloride afforded 4-chloro-4-methyl-5-methylene-1,3-dioxolan-2-one (3) in good yield. Compound 3 underwent allylic rearrangement to afford 1c quantiatively. The overall yield of 1c from 2 was approximately 80%.
- 公益社団法人日本薬学会の論文
- 1988-01-25
著者
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井内 浤二
Pharmaceuticals Research Center, Kanebo Ltd.
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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池田 昇司
Pharmaceuticals Reseach Center Kanebo Ltd.
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武部 靖
Pharmaceuticals Reseach Center Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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平山 良一
Pharmaceuticals Reseach Center Kanebo Ltd.
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坂本 文夫
Pharmaceuticals Reseach Center, Kanebo Ltd.,
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井内 浤二
Pharmaceuticals Reseach Center Kanebo Ltd.
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坂本 文夫
Pharmaceuticals Research Center Kanebo Co. Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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