2-Oxo-1,3-dioxols as Specific Substrates for Measurement of Arylesterase Activity

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概要

• 論文の詳細を見る

• Various 4-arylthiomethyl-2-oxo-1,3-dioxole derivatives IIIa-o were synthesized. Their hydrolysis rates by arylesterase (EC 3.1.1.2) and cholinesterase (EC 3.1.1.8) in human serum were evaluated. Some of them were not hydrolyzed by cholinesterase, but were hydrolyzed easily by arylesterase.Among the substrates, sodium 4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methylthio)benzenesulfonate (IIIg) was selected for its substrate reactivity toward arylesterase and its good water solubility. In addition, neither aliesterase (EC 3.1.1.1), acetylesterase (EC 3.1.1.6) nor cholesterol esterase (EC 3.1.1.13)hydrolyzed the compound. IIIg is thus concluded to be a specific substrate for arylesterase.Our assay system for serum arylesterase using IIIg can be readily applied to an automatic analyzer in the diagnosis of liver cirrhosis.

• 公益社団法人日本薬学会の論文
• 1991-06-25

著者

• 塚本 悟郎

  Pharmaceuticals Research Center, Kanebo Ltd.

• 塚本 悟郎

  New Drug Research Laboratories Kanebo Ltd.

• 坂本 文夫

  Pharmaceuticals Reseach Center, Kanebo Ltd.,

• 外村 幹雄

  Pharmaceuticals Research Center, Kanebo Co., Ltd.

• 田口 雅裕

  Pharmaceuticals Research Center, Kanebo, Ltd.

• 坂本 文夫

  Pharmaceuticals Research Center Kanebo Co. Ltd.

• 河井 浩

  Pharmaceuticals Research Center, Kanebo Co., Ltd.

• 北村 幹弥

  Pharmaceuticals Research Center, Kanebo Co., Ltd.

• 外村 幹雄

  Pharmaceuticals Research Center Kanebo Co. Ltd.

• 河井 浩

  Pharmaceuticals Research Center Kanebo Co. Ltd.

• 田口 雅裕

  Pharmaceuticals Research Center Kanebo Co. Ltd.

• 北村 幹弥

  Pharmaceuticals Research Center Kanebo Co. Ltd.

• 塚本 悟郎

  Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.

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