Novel 4-Substituted 2-Piperazinylquinazolines as Potent Anticonvulsive and Antihypoxic Agents

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概要

• 論文の詳細を見る

• Several types of quinazoline derivatives were prepared and examined for anticonvulsive and antihypoxic activities. Many compounds showed potent anticonvulsive activity, and their anticonvulsive profile is similar to that of phenytoin. The analysis of quantitative structure-activity relationships indicated that the anticonvulsive activity was parabolically related to the lipophilicity of the compounds. Most of the 4-alkoxyquinazolines showed potent anticonvulsive and antihypoxic activities. It is confirmed that there is a good correlation between the potencies of these activites.

• 社団法人日本薬学会の論文
• 1990-05-25

著者

• 原 英彰

  鐘紡(株)薬品開発第一研究所薬理研究部

• 原 英彰

  Pharmaceuticals Research Center Kanebo Ltd.

• 洲加本 孝幸

  鐘紡(株)薬品開発第一研究所薬理研究部

• 堀 学

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 家村 隆一

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 尾崎 昭夫

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 洲加本 孝幸

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 大高 博

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 大高 博

  New Drug Research Laboratories Kanebo Ltd.

• 堀 学

  New Drug Research Laboratories, Kanebo Ltd.,

• 尾崎 昭夫

  New Drug Research Laboratories, Kanebo Ltd.,

• 堀 学

  New Drug Research Laboratories Kanebo Ltd.

• 尾崎 昭夫

  New Drug Research Laboratories Kanebo Ltd.

• 家村 隆一

  Pharmaceuticals Research Center Kanebo Ltd.

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