Interaction of Drugs with Polymers. II. The Phase Separation of Polyacrylic Acid by Cationic Drugs
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概要
- 論文の詳細を見る
Phase separation of PAA by various cationic drugs has been investigated as a function of temperature, polymer and added drug concentration. There exists a temperature Tp at which the PAA-drug aqueous solution separates into two phases (liquid-liquid or solid-liquid). The Tp changes remarkably not only with PAA or added drug concentration, but also with the basic structure of drug molecules or valences of drug cations. The decreasing order of the Tp is O-benzoylthiamine>thiamine>N-methylephedrine>ephedrine>piperidine>N, N-dimethylaniline>N-methylaniline≒aniline>pyridoxine≒pyridine.
- 社団法人日本薬学会の論文
- 1966-04-25
著者
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田中 信夫
Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.
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平田 五一
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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内海 勇
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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平田 五一
Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.
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内海 勇
Pharmaceutical Research Laboratory Tanabe Seiyaku Co., Ltd.
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