高分子と医薬品との相互作用(第4報) : 塩溶液中の橋かけポリアクリル酸の膨潤

概要

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By the use of a crosslinked sodium polyacrylate, with a mean polymerization degree of 4850 between two adjacent crosslinks, as a sample, in the system containing various inorganic and organic salts, hydrochloric acid, and sodium hydroxide, examination was made on the effect of the concentration of the salt added, C_s, on the degree of equilibrium swelling, Q_v, of these salts. In the system of univalent-univalent inorganic salts, there was no difference in Q_v according to the kind of cations present but a slight difference in Q_v was seen according to the kind of anions present at around 0.1 N of C_s. This difference appeared markedly in the organic salt system, and the values of Q_v decreased in the order of sodium carbazol-chrome sulfonate>sodium acetate≒sodium benzoate>dl-methylephedrine hydrochloride>ephedrine hydrochloride>pyridoxine hydrochloride. In the system of bivalent-univalent salts, decrease of Q_v was marked and its values were not affected by C_s. In the univalent-univalent salt system, relationship between Q_v^5/_3 and C_s^2/_3 was linear, which was found not to agree with the swelling theory of Vermaas and Hermans.
社団法人日本薬学会の論文
1969-11-25