複合体に関する研究(第10報) : 複合体の消化管吸収についてその1

概要

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Effect of complex formation on the absorption of drugs was examined by perfusion with rat small intestine. Following combinations were used as the model drugs : Pyrazolone derivatives (sulpyrin, antipyrine, 4-aminoantipyrine, 4-methylaminoantipyrine, and aminopyrine)-salicylic acid, pyrazolone derivatives-benzoic acid, pyrazolone derivatives-riboflavin phosphate, and salicylamide-nicotinamide derivatives (nicotinamide and NN'-dimethyl-3,5-pyridinedicarboxamide). It was found that (a) salicylic and benzoic acid accelerated the rate of absorption of 4-methylaminoantipyrine and reduced that of antipyrine and 4-aminoantipyrine, (b) sulpyrin reduced the absorption of saliclyic acid, (c) riboflavin phosphate reduced the absorption of sulpyrin and 4-aminoantipyrine, and (d) nicotinamide reduced the absorption of salicylamide. These facts were explained by the correlation with orgnaic solvent/isotonic buffer solution partition coefficients.
社団法人日本薬学会の論文
1968-05-25