固体状態の医薬品の安定性に関する研究(第1報) : アセチルサリチル酸の分解

概要

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Acetylsalicylic acid, which undergoes decomposition by acid-base catalyzed reaction, was mixed in powdered state with buffer salts of various pH and it was found that decomposition at a definite temperature and humidity was dependent on the pH of the buffer salts to be mixed, as is the case in a solution. Decompositions of acetylsalicylic acid in buffer agents was found to follow the pseudo-first order reaction after a lag period. Reaction rate constants in the atmosphere of saturated potassium nitrate solution at 30,35,40,and 45°were measured and the values were found to be dependent on temperature. Arrhenius plots gave almost the straight line. However, this plots deviate from straight line if phase variation occurred within the range of reaction temperature. The apparent activation energy of this reactions calculated from the slope of the straight line was a value larger than that of the reaction in solution.
社団法人日本薬学会の論文
1966-04-25