Thiamine disulfdeにかんする研究(XLII)ビタミンB_1およびB_1誘導体負荷時の臓器中コカルボキシラーゼの消長

概要

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Formation of cocarboxylase (CoC) in various tissues of the thiamine deficient rats after intravenous administrations of thiamine, CoC, and O-butyrylthiamine disulfide (BuTDS) has been investigated by means of enzymatic assay. CoC levels and patterns of their change after the administration of CoC itself were quite similar to those of thiamine in the tissues, such as blood, brain, heart, kidney and liver. It suggests that the given CoC is hydrolyzed to thiamine or thiamine monophosphate in blood or the tissues, and uptaken CoC without being hydrolyzed is little. It was recognized that CoC levels after the administration of BuTDS, lipophylic and easily uptakable by erythrocytes, had been maintained higher than those of thiamine or CoC. By the administration of each type of thiamines investigated, CoC levels in blood, kidney and liver reached maximum within 3 hours, but in heart and brain incresed gradually for 24 hours. Therefore the change of CoC levels had shown different paffern in each tissue.
日本ビタミン学会の論文
1970-07-25