20.人体血清, 組織中のD_3代謝物のD_3代謝物の分布

概要

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In the previous paper, it was reported that the enzyme, which catalyzes the reduction of disulfide type thiamine derivatives by glutathione, occurs in rat liver supernatant. In this paper, it was shown that the reaction of S-acyl type thiamine derivatives and glutathione was accelerated by the similar enzyme in rat liver. The specific activity of this enzyme for S-acyl type thiamine derivatives was 20-60 times greater than that of thioesterase and it seemed that the conversion to thiazole type thiamine of S-acyl type thiamine derivatives in the body may be performed by this enzyme rather than thioesterase. On a SE-Sephadex column chromatography, the activity for the disulfide type thiamine derivatives was separated into four fractions, the three of which were active for S-acylthiamine. It was assumed that the two activities in the three fractions were due to the same enzyme, respectively,
日本ビタミン学会の論文
1970-05-25