複合体に関する研究(第15報) : 酸アミド類の溶解補助作用と量子化学的性質その1

概要

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In order to clarify the solubilizing action of acid amides, quantum chemical approach using LCAO-MO method was made and the following results were obtained. 1) On the basis of molecular orbital considerations, it was found that acid amides act as electron acceptors. 2) Solubilizates which have electron-donating tendency towards acid amide formed more stable complexes than solubilizates which have electron-accepting tendency. 3) Formation constants of complexes had a linear relationship with parameters of energy level of the lowest vacant molecular orbitals (λιυ) of aromatic acid amides, and π-electron densities of the oxygen atom in acid amide groups. 4) The extent of planarity of the solubilizate molecules was correlated to formation constants of complexes.
社団法人日本薬学会の論文
1971-02-25