複合体に関する研究(第19報)N-置換酸アミド類の溶解補助作用に関する研究

概要

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The solubilizing action of N-substituted nicotinamides was studied in relation to the adsorption of nicotinamides by carbon black from aqueous solution, and to the partition coefficients in CHCl_3-H_2O and octanol-H_2O systems. The adsorption by carbon black was reversible and isotherms were well expressed by the Langmuir eqution. Amount of N-substituted nicotinamides adsorbed by carbon black increased with the chain length of the substituents in N-substituted nicotinamides. Formation constants of solubilizatenicotinamide complexes had a good correlation with the adsorbability of N-subetituted nicotinamides, except N, N-dialkyl substituents, by carbon black and with the partition coefficients in CHCl_3-H_2O and octanol-H_2O systems.
社団法人日本薬学会の論文
1973-11-25