Intestinal Absorption of a New Anticholinergic Agent, Timepidium Bromide. I. Various Factors Influencing Absorption
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概要
- 論文の詳細を見る
Various factors influencing intestinal absorption of a quaternary anticholinergic agent, timepidium bromide (TB), were studied in rats using in situ intestinal loop technique. Bile, mucin and intestinal mucous material significantly decreased the amount of TB absorbed from intestinal loops. This decrease was assumed to be due to bonding of TB cation to anionic groups of bile constituents, mucin and intestinal mucous membranes. Gastric juice and hydrochloric acid significantly increased the absorption of TB. Organic acids, such as citric, malic and acetic acid, also increased the absorption of TB. The greatest increase in absorption of TB was observed in the presence of citric acid. Citric acid had this facilitatory effect only when added to the medium in relatively high concentrations (0.05M) and at relatively low pH. However, this increased absorption was shown not to be simply the result of an acidic intestinal environment or irreversible changes in the gut wall.
- 公益社団法人日本薬学会の論文
- 1978-02-25
著者
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玉木 元
Biological Research Laboratory, Tanabe Seiyaku Co,. Ltd.
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飯 照彦
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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Tamaki Hajime
Pharmacological Resarch Laboratory Tanabe Seiyaku Co. Ltd.
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飯 照彦
Biological And Chemical Research Laboratories Tanabe Seiyaku Co. Ltd.:(present Address)department Of
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Tamaki H
Pharmacological Research Laboratory Tanabe Seiyaku Co. Ltd.
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