RELATIONSHIP BETWEEN PHARMACOLOGICAL ACTIVITY AND BLOOD LEVEL OF A NEW ANTICHOLINERGIC AGENT, TIMEPIDIUM BROMIDE (SA-504), IN CATS
スポンサーリンク
概要
- 論文の詳細を見る
Relationship between pharmacological activities and blood levels of a new anticholinergic agent (SA-504). as well as excretion, and distribution in the gastro-intestinal tract were investigated in cats. The time courses of inhibitory effect of SA-504 on gastric motility were closely related to those of blood levels of SA-504 after intragastric administration of <SUP>3</SUP>H-labelled compound. Effects of SA-504 on the pupil of the eye, heart rate and blood pressure were much less than its inhibitory effects on gastric motility. The contents of <SUP>3</SUP>H-SA-504 in the gastric wall were extremely high as compared with those in the blood and heart. About 23 % of the radioactivity administered orally as <SUP>3</SUP>H-SA-504 was excreted into the bile and 20% into the urine during a 24 hour period, suggesting that more than 4000 of the dose is absorbed from the alimentary tract of cats within 24 hours.
- 社団法人 日本薬理学会の論文
著者
-
Tamaki Hajime
Pharmacological Resarch Laboratory Tanabe Seiyaku Co. Ltd.
-
MESHI Teruhiko
Drug Metabolism Research Laboratory, Tanahe Seivaku Co., Ltd.
-
TAMAKI Hajime
Pharmacological Research Laboratory, Tanahe Seivaku Co., Ltd.
関連論文
- Synthesis of Novel Pyridotriazepinones as Antisecretory Agents(Organic,Chemical)
- Antiulcer Activity of Dehydroabietic Acid Derivatives
- Effects of Ecabet Sodium (TA-2711), a New Antiulcer Agent, on Gastrointestinal Mucosal Prostanoid Production and Morphology in Rats
- Syntheses and Antiulcer Activities of 2-Aminonorbornene Derivatives
- Intestinal Absorption of a New Anticholinergic Agent, Timepidium Bromide. II. Enhancement of Absorption
- Intestinal Absorption of a New Anticholinergic Agent, Timepidium Bromide. I. Various Factors Influencing Absorption
- Effects of Cholecystokinin (CCK)-JMV-180 on the CCK Receptors of Rabbit Pancreatic Acini and Gallbladder Smooth Muscle
- Mechanism of Anti-urease Action by the Anti-ulcer Drug Ecabet Sodium
- Effect of a Combination of Ecabet Sodium and Cimetidine on Experimentally Induced Gastric Lesions and Gastric Mucosal Resistance to Ulcerogenic Agents in Rats
- RELATIONSHIP BETWEEN PHARMACOLOGICAL ACTIVITY AND BLOOD LEVEL OF A NEW ANTICHOLINERGIC AGENT, TIMEPIDIUM BROMIDE (SA-504), IN CATS
- GASTRIC SECRETION AND DUODENAL ULCER FORMATION INDUCED BY CYSTEAMINE IN RATS
- Effects of trimebutine maleate (TM-906) on the spontaneous contraction of isolated guinea pig colon.