Studies on Metabolism of Thiamine in Rats. I. Cleavage of Thiamine Molecule in Vivo
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概要
- 論文の詳細を見る
It was found that in the rat about 50% of orally administered thiamine was decomposed into 4-methyl-5β-hydroxyethylthiazole (HT) and pyrimidyl derivative. It was demonstrated that 2-methyl-4-amino-5-hydroxymethylpyrimidine (HMP) was formed from thiamine as one of pyrimidyl derivatives. However, the amount of excreted HMP was extremely small as compared to that of excreted HT. It was concluded that the main cleavage of thiamine was not a direct hydrolysis into HT and HMP.
- 公益社団法人日本薬学会の論文
- 1968-08-25
著者
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飯 照彦
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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佐藤 善重
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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飯 照彦
Biological And Chemical Research Laboratories Tanabe Seiyaku Co. Ltd.:(present Address)department Of
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佐藤 善重
Biological Laboratory, Tanabe Seiyaku Co., Ltd.
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