A NOVEL INVERSE TYPE DIELS-ALDER REACTION OF ETHYL (E)-3-(1,3-BENZOTHIAZOL-2-YL)-3-CYANOPROPENOATE AS A HIGHLY REACTIVE 1-AZA-1,3-BUTADIENE

スポンサーリンク

概要

• 論文の詳細を見る

• Diels-Alder reactions of ethyl (E)-3-(1,3-benzothiazol-2-yl)-3-cyanopropenoate (2) as a 1-aza-1,3-butadiene are described. The diene (2), bearing electron-withdrawing ester group, reacts with electron-rich dienophiles (3a-d) under extremely mild conditions to give corresponding cycloadducts (4a-d) in high yields with high regio- and endo-selectivities. Treatment of 2 with electron-donating allyl alcohols (5a, b) causes tandem transesterification and intramolecular cycloaddition to afford cis-fused polycyclic systems (6a, b) in one step.

• 公益社団法人日本薬学会の論文
• 1995-10-15

著者

• 坂本 正徳

  Meiji College of Pharmacy

• 坂本 正徳

  明治薬科大学

• 長野 真弓

  Meiji College Of Pharmacy

• 鈴木 陽子

  Meiji College Of Pharmacy

• 田村 修

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Tamura Osamu

  Meiji College Of Pharmacy

• 田村 修

  Meiji College of Pharmacy

• Sakamoto M

  Meiji College Of Pharmacy

関連論文

• Protective Effect of Prostaglandin EP_4-Receptor Agonist on Anti-glomerular Basement Membrane Antibody-Associated Nephritis
• Identification and Characterization of Carbohydrate Molecules in Mammalian Cells Recognized by Dengue Virus Type 2
• Addition Reactions of Heterocumulenes. IV. Reactions of Diketene and Diphenylketene with N-Aryl-S, S-dimethylsulfilimines
• The New Role of Disodium Cromoglycate in the Treatment of Adults with Bronchial Asthma
• In Vitro Inhibition of Human Influenza A Virus Infection by Fruit-Juice Concentrate of Japanese Plum (Prunus mume SIEB. et ZUCC)(Microbiology)
• Clarithromycin Inhibits Progeny Virus Production from Human Influenza Virus-Infected Host Cells(Microbiology)
• Suppression of the Biosynthesis of Cellular Sphingolipids Results in the Inhibition of the Maturation of Influenza Virus Particles in MDCK Cells(Highlighted paper selected by Editor-in-chief,Biochemistry)
• In Vitro and in Vivo Inhibitory Effects of Disodium Cromoglycate on Influenza Virus Infection(Pharmacology)
• Addition Reactions of Heterocumulenes. III. Reaction of Diketene with Formamidine Derivatives
• 1,4-Cycloaddition Reactions of Enamine with Compounds containing the Double Bond System C=N-C=N
• Addition Reactions of Heterocumulenes. II. 1,4-Cycloaddition Reactions of Diphenylketene with Azadienes
• 1,4-Cycloaddition Reactions of Diphenylketene with Azadienes
• Addition Reactions of Heterocumulenes. I. Cycloaddition Reaction of Dimethylketene with α-Diimines
• 含窒素共役系の反応(第4報)共役1,2-Diimine類とイソシアナート類との反応
• 含窒素共役系の反応(第8報)Dimethyl Inidazole-4,5-dicarboxylateとAnetholeとの反応生成物の構造について
• 含窒素共役系の反応(第7報)N-CinnamylidenemethylamineとN-Methyl-maleimideとめ付加体について
• 含窒素共役系の反応(第6報)2,3-Diphenyl-5,6-dihydropyrazineとDiethyl FumarateまたはN-Methylmaleimideとの付加体の立体構造について
• A Novel Oxidative Intramolecular [4+2]Cycloaddition of Silylene-Protected Dihydroxystyrene Derivatives Leading to peri-Hydroxy Polycyclic Aromatic Compounds : A Synthesis of the ABCD Ring System of Frederucamycin A
• Effects of KD3-671, an Angiotensin II Type 1 Receptor Antagonist, on Anti-Thy-1 Nephritis in Rats
• Studies on Conjugated Nitriles. V. Reaction of 3-Benzoyl-and 3-Ethoxycarbonylacrylonitriles with Enamines
• Studies on Conjugated Nitriles. IV. Reaction of Ethyl Cyanoformate with Organomagnesium, -zinc, and-cadmium Reagents, and Phosphonium Ylide
• Reaction of 1-Alkyl-3,4-dihydroisoquinolines with 4-Nitrobenzoyl Cyanide and Diketene
• Reaction of N-(1-Phenylalkylidene)benzylamines with Benzoyl Cyanides
• Association study of the C3 gene with adult and childhood asthma
• ペリ環状反応の化学とその複素環化合物合成への応用
• Photocyclization Reactions of Epoxy Nitriles via Carbonyl Ylides. Formation of Spiroketals, Spiroethers, and a Spirolactone
• Studies on Conjugated Nitriles. VI. Reaction of 2-Methylquinoline and Related Compounds with Acyl Cyanides
• Addition Reactions of Diketene. IV. Reaction of Diketene with Thioureas, Thioamide, and Aminothiol
• 含窒素共役系の反応(第9報)Furazan誘導体とAnetholeとの環化付加反応について
• 含窒素共役系の反応(第5報) : N, N'-Bis(p-dimethylaminophenyl)ethylenediimineとp-Benzoquinoneとの反応生成物の構造について
• 含窒素共役系の反応(第3報) : 共役Schiff Baseとジフェニルケテンとの反応
• 含窒素共役系の反応(第2報) : 共役Schiff Baseとアセチレンジカルボン酸ジメチルエステルとの反応
• 含窒素共役系の反応(第1報) : 2,3-Diphenyl-5,6-dihydropyrazineとDiethyl Fumarateとの反応
• P-564 MULTI-DIMENSIONAL HPLC MAPPING METHOD FOR STRUCTURAL ANALYSES OF N-GLYCANS AND ITS APPLICATIONS TO N-GLYCOSYLATION PROFILING OF ORGANISMS AND TISSUES
• Chemistry of O-Silylated Ketene Acetals : A Stereoselective Synthesis of Optically Active Carbapenem Antibiotics, (+)-Thienamycin and (+)-PS-5
• Chemistry of O-Silylated Ketene Acetals : A Mild and Convenient Synthesis of β-Lactam Antibiotics
• Chemistry of O-Silylated Ketene Acetals : : A Novel Intramolecular Pummerer-Type Reaction of ω-Carbamoylsulfoxide Leading to α-Thiolactams
• Chemistly of O-Silylated Ketene Acetals : Stereocontrolled Synthesis of 3-Benzoylamino-2,3-dideoxy-pentoses by a 1,3-Addition to Chiral Nitrones
• The Chemistry of O-Silylated Ketene Acetals : Synthesis of N-Benzoyl-L-daunosamine
• Chemistry of O-Silylated Ketene Acetals. Novel Chemical Transformation of Vinyl Sulfoxides and Related Sulfoxides(Organic,Chemical)
• 薬学教育の現状をどう打開するか(入試制度と薬学教育)
• Insufficient Expression of Cyclooxygenase-2 Protein Is Associated With Retarded Degradation of Aggregated Protein in Diabetic Glomeruli
• Increase in the Deposition of Aggregated Protein in the Glomeruli of Spontaneously Diabetic Mice
• Sulfatide and Its Synthetic Analogues Recognition by Moraxella catarrhalis
• Alkaloid from Thermoactinomyces Species
• A NOVEL INVERSE TYPE DIELS-ALDER REACTION OF ETHYL (E)-3-(1,3-BENZOTHIAZOL-2-YL)-3-CYANOPROPENOATE AS A HIGHLY REACTIVE 1-AZA-1,3-BUTADIENE
• BENZYLIDENECYANOMETHYL-1,3-BENZAZOLES AS 1-AZA-1,3-BUTADIENES
• Association of the RIP2 Gene with Childhood Atopic Asthma
• Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma
• An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway
• Chemistry of O-Silylated Ketene Acetals : Preparation of α-Siloxy Phenyl Sulfides and Methyl 3-(Phenylthio) butyrates from Alkyl Phenyl Sulfoxides
• 高立体選択的な窒素官能基の導入法の開発
• Ring-Chain Tautomerism and Some Reactions of 2-Hydroxyindoline Derivatives(Organic,Chemical)
• New Zinc (II) Complexes with Tetradentate Amino Acid Derivatives: Structure Characterization, Solution Chemistry, and in vitro Insulinomimetic Activity
• Oxidation of 1-Acylindoles with Oxodiperoxomolybdenum (VI), MoO_5・HMPA. Preparation of 2,3-Dihydroxyindoline and Indoxyl Derivatives
• SYNTHESIS OF 1,2-DIHYDRO-2-ALLYLINDOL-3-ONES USING IN SITU CLAISEN REARRANGEMENT OF 1,2-DIHYDROINDOL-3-ONES WITH ALLYL ALCOHOLS
• Studies on Conjugated Nitriles. VII. Lewis Acid-Promoted Reaction of Active Methylene Compounds with Diethyl Phosphorocyanidate; Preparation of α, β-Unsaturated α-Aminophosphonates
• A Novel Synthesis of 1-Acylindoxyls
• Oxidation of Furan, Pyrrole, Thiophene, Benzo [b] furan, and Benzo [b] thiophene with Oxodiperoxomolybdenum (VI), MoO_5・HMPA
• Stereospecific Epoxidation of cis-2-Butene-1,4-diones to cis-2,3-Epoxybutane-1,4-diones with Oxodiperoxomolybdenum (VI), MoO_5・H_2O・HMPA
• Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case–control study
• Oxidation of Indoles with Oxodiperoxomolybdenum (VI), MoO_5・HMPA. Preparation of 2-Hydroxyindoxyl and Isatogen Derivatives
• STEREO CHEMISTRY OF HYDROGEN INTRODUCTION AT C-25 DURING CHOLESTEROL BIOSYNTHESIS IN HIGHER PLANTS
• 第7回薬物の分子設計と新薬開発に関する韓日合同シンポジウム
• 大学側と受入側との意見交換の場として必要(薬学会年会に教育部会を置くことの是非)
• 6年制に向けた教育体制の充実--薬学教育の現状を考える (特集 薬学教育の転換期)
• Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus
• 2-Acetyl-1-naphthoic and 2-Acetyl-3,4-dihydro-1-naphthoic Acid.
• Replication of genetic association studies in asthma and related phenotypes

もっと見る 閉じる

スポンサーリンク