A Novel Synthesis of 1-Acylindoxyls
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概要
- 論文の詳細を見る
A novel and efficient synthesis of 1-acylindoxyls (3) from 1-acylindoles (1) is described. The procedure involves the demethoxylation with stannic chroride of 1-acyl-3-hydroxy-2-methoxy-indoline (2), which were obtained by the MoO_5 oxidation of 1in methoanol. Since the MoO_5 oxidation of 2-substituted 1-acylindoles (1f and 1g) gave not the corresponding indolines (2f and 2g), but 2-hydroxyindoxyls (4f and 4g), 2f and 2g were obtained by the methylation of 4f and 4g with diazomethane to give 5f and 5g, followed by the reduction of 5f and 5g with sodium borohydride, respectively.
- 公益社団法人日本薬学会の論文
- 1986-04-25
著者
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長谷川 敦
Faculty of Pharmaceutical Sciences, Chiba University
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川崎 知己
明治薬科大学
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坂本 正徳
Meiji College of Pharmacy
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川崎 知己
Meiji College of Pharmacy
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長谷川 敦
Faculty Of Pharmaceutical Sciences Chiba University
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簡 俊生
Meiji College of Pharmacy
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長谷川 敦
Meiji College of Pharmacy
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