Chemistry of O-Silylated Ketene Acetals : A Mild and Convenient Synthesis of β-Lactam Antibiotics
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概要
- 論文の詳細を見る
β-Amido sulfoxides (1) reacted with O-silylated ketene acetal (16) in dry acetonitrile in the presence of a catalytic amount of zinc iodide to give the 4-phenylthioazetidin-2-ones (17). Oxidation of 17 with m-chloroperbenzoic acid gave the corresponding sulfoxides (18), which were treated with 16 to give the azetidin-2-one esters (20), known precursors of PS-5-type carbapenem antibiotics.
- 社団法人日本薬学会の論文
- 1991-09-25
著者
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北 泰行
Faculty of Pharmaceutical Sciences, Osaka University
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北 泰行
大阪大学大学院薬学研究科
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北 泰行
大阪大学薬学部
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Kita Yasuyuki
Graduate School Of Pharmaceutical Sciences Osaka University Yamadaoka
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田村 修
Faculty of Pharmaceutical Sciences, Osaka University
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三木 隆
Faculty Of Pharmaceutical Sciences Osaka University
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柴田 哲男
Faculty of Pharmaceutical Sciences, Osaka University
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田村 修
Faculty Of Pharmaceutical Sciences Osaka University
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田村 修
Faculty Of Pharmaceutical Sciences Kanazawa University
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北 泰行
Faculty Of Pharmaceutical Sciences Osaka University
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