超原子価ヨウ素試薬を用いるフェノール類の酸化的カップリング反応の開発とAmaryllidaceae Alkaloids合成への応用
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概要
- 論文の詳細を見る
Hypervalent iodine (III) reagents nowadays are used extensively in the field of organic chemistry. Especially, phenyliodine(III)diacetate (PIDA) or phenyliodine (III) bis(trifluoroacetate) (PIFA) have received much attention because of their reactivities similar to heavy metal reagents or anodic oxidation, low toxicity, ready availability and easy handling. In the continuous study of our oxidative phenolic coupling reactions using a hypervalent iodine (III) reagents, a versatile synthetic procedure for the galanthamine-type Amaryllidaceae alkaloids was accomplished. The first total synthesis of (±)-sanguinine and the total syntheses of (±)-galanthamine, (±)-narwedine, (±)-lycoramine, and (±)-norgalanthamine were also successfully carried out.
- 社団法人日本薬学会の論文
- 2000-10-01
著者
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北 泰行
大阪大学大学院薬学研究科
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北 泰行
大阪大学薬学部
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当麻 博文
大阪大学大学院薬学研究科分子合成化学分野
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有澤 光弘
大阪大学大学院薬学研究科分子合成化学分野
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Kita Yasuyuki
Graduate School Of Pharmaceutical Sciences Osaka University Yamadaoka
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