Synthetic Application of Lithiation Reactions : A Convenient Synthesis of 3,4-Dihydro-5-hydroxycarbostyril, 1,2,3,4-Tetrahydro-5-hydroxy-2-oxo-1,7-naphthyridine, and Methyl 3-Methoxypyridine-4-carboxylate
スポンサーリンク
概要
- 論文の詳細を見る
3,4-Dihydro-5-hydroxycarbostyril (3), a key intermediate for a clinically used β-receptor blocking agent (1), and its 7-aza analog (4) were prepared by an acid-catalyzed cyclization of the N-pivaloylamino-esters (17 and 19), which were obtained by using organolithiation of 3-methoxy-5-(pivaloylamino) pyridine and m-pivaloylanisidine, followed by Wittig and catalytic hydrogenation reactions. Some related pyridine derivatives (15 and 24) were also prepared.
- 公益社団法人日本薬学会の論文
- 1982-04-25
著者
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田村 恭光
Faculty Of Pharmaceutical Sciences Osaka University
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北 泰行
大阪大学大学院薬学研究科
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藤田 昌宣
Faculty Of Pharmaceutical Sciences Osaka University
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陳 麟慶
Faculty Of Pharmaceutical Sciences Osaka University
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北 泰行
Faculty Of Pharmaceutical Sciences Osaka University
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