Lipase-Catalyzed Asymmetric Desymmetrization of Prochiral 2,2-Disubstituted 1,3-Propanediols Using 1-Ethoxyvinyl Benzoate
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概要
- 論文の詳細を見る
The lipase-catalyzed asymmetric desymmetrization of the prochiral 2,2-disubstituted 1,3-propanediols was studied using various types of 1-ethoxyvinyl esters (1a-i). Although 1a-e with aliphatic acyl groups were not sufficient, use of the benzoate (1f) in combination with Candida rugosa lipases converted acyclic diols (2,6) and cyclic diols (11-14) to the optically active compounds (3f, 7f, 15f-18f), bearing a quaternary carbon center, with moderate-to-high optical yields. These products were fairly stable against racemization under acidic conditions.
- 社団法人日本薬学会の論文
- 2000-10-01
著者
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北 泰行
大阪大学大学院薬学研究科
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北 泰行
大阪大学薬学部
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赤井 周司
大阪大学大学院薬学研究科
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KITA Yasuyuki
Graduate School of Pharmaceutical Sciences, Osaka University
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AKAI Shuji
Graduate School of Pharmaceutical Sciences, Osaka University
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Kita Yasuyuki
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Kita Yasuyuki
Graduate School Of Pharmaceutical Sciences Osaka University Yamadaoka
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NAKA Tadaatsu
Graduate School of Pharmaceutical Sciences, Osaka University
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TAKEBE Yasushi
Graduate School of Pharmaceutical Sciences, Osaka University
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Naka Tadaatsu
Graduate School Of Pharmaceutical Sciences Osaka University
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Naka T
Medicinal Chemistry Research Laboratories Takeda Chemical Industries Ltd.
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