Asymmetric Synthesis by the Intramolecular Haloetherification Reaction of Ene Acetal : Discrimination of Prochiral Dienes in Cyclohexane Systems

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概要

• 論文の詳細を見る

• A novel asymmetric synthesis of the cyclohexane derivative functionalized by some substituents has been developed from the diene acetals (1), prepared from the corresponding diene aldehyde and (+)-hydrobenzoin. The treatment of 1 with NBS in the presence of MeOCH_2CH_2OH predominantly afforded 2 in a stereoselective manner. Subsequent alkylation of the methoxyethoxy group produced the optically active cyclohexene compounds (3) in good yields. The stereoselective chemical modification of the remaining olefin in 3 was made by OsO_4-oxidation.

• 社団法人日本薬学会の論文
• 2005-08-01

著者

• 藤岡 弘道

  大阪大学大学院薬学研究科

• KITA Yasuyuki

  Graduate School of Pharmaceutical Sciences, Osaka University

• FUJIOKA Hiromichi

  Graduate School of Pharmaceutical Sciences, Osaka University

• Kita Yasuyuki

  Graduate School Of Pharmaceutical Sciences Osaka Univ.

• Kita Yasuyuki

  Graduate School Of Pharmaceutical Sciences Osaka University

• Sawama Yoshinari

  Graduate School of Pharmaceutical Sciences, Osaka University

• KOTOKU Naoyuki

  Graduate School of Pharmaceutical Sciences, Osaka University

• KITAGAWA Hidetoshi

  Graduate School of Pharmaceutical Sciences, Osaka University

• OHBA Yusuke

  Graduate School of Pharmaceutical Sciences, Osaka University

• WANG Tsung

  Graduate School of Pharmaceutical Sciences, Osaka University

• NAGATOMI Yasushi

  Graduate School of Pharmaceutical Sciences, Osaka University

• Wang Tsung

  Graduate School Of Pharmaceutical Sciences Osaka University

• Kitagawa Hidetoshi

  Graduate School Of Pharmaceutical Sciences Osaka University

• Ohba Yusuke

  Graduate School Of Pharmaceutical Sciences Osaka University

• Kotoku Naoyuki

  Graduate School Of Pharmaceutical Sciences Osaka University

• Nagatomi Yasushi

  Graduate School Of Pharmaceutical Sciences Osaka University

• Sawama Yoshinari

  Graduate School Of Pharmaceutical Sciences Osaka University

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