Practical Synthesis of Optically Pure 1- and 3-Substituted Dihydroorotic Acids
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概要
- 論文の詳細を見る
Various optically pure 3-substituted dihydroorotic acids (9,12) were synthesized by the N-alkylation and Mitsunobu reaction of optically active benzyl or tert-butyl dihydroorotate (6,10), followed by deprotection of the ester group.Moreover, optically pure 1-methyl (16,17) and 1-ethyl (19) dihydroorotic acids were obtained by an optical resolution method.
- 社団法人日本薬学会の論文
- 1989-07-25
著者
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松本 和男
田辺製薬医薬育成所
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松本 和男
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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鈴木 護
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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前田 ひろし
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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近藤 一彦
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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菅野 紘
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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近藤 一彦
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
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鈴木 護
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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前田 ひろし
Faculty Of Pharmaceutical Sciences Osaka University
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菅野 紘
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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- Practical Synthesis of Optically Pure 1- and 3-Substituted Dihydroorotic Acids
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