A Synthesis of 2-Substituted 2-Aminoethanol Derivatives Having Inhibitory Activity against Protein Kinase C
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概要
- 論文の詳細を見る
A series of 2-aminoethanol derivatives was synthesized and their inhibitory activities against protein kinase C were investigated. Among these compounds, 2-endo-hexadecylamino-5-norbornene-2-exo-methanol (4h) and 2-endo-hexadecylamino-5-norbornene-2,3-exo-dimethanol (4i) inhibited protein kinase C at the IC_<50> values of 2×10^<-5> and 1×10^<-5> M, respectively, but not protein kinase A at a concentration of 1×10^<-3> M. The structure-activity relationships are discussed.
- 社団法人日本薬学会の論文
- 1992-01-25
著者
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近藤 一彦
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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岩崎 為雄
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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近藤 一彦
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
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西谷 喬
Research Laboratories of Tanabe Seiyaku Co., Ltd.,
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山崎 裕義
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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佐藤 忠司
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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佐藤 忠司
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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西谷 喬
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
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岩崎 為雄
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
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Kondo K
Nagoya City Univ. Nagoya Jpn
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Iwasaki T
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
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山崎 裕義
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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Kondo Kaoru
School Of Medicine Kanazawa University
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