A SYNTHESIS OF 2-ENDO-AMINO-2-EXO-HYDROXYMETHYLNORBORNENES HAVING INHIBITORY ACTIVITY AGAINST PROTEIN KINASE C
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概要
- 論文の詳細を見る
2-endo-Hexadecylamino-2-exo-hydroxymethylnorbornene (1a) was synthesized from 2-acetamidonorbornene-2-carboxylic acid methyl ester (2) in a good overall yield. 2-endo-Hexadecylamino-2,3-exo-bis(hydroxymethyl)norbornene (1b) was synthesized starting from dimethyl acetamidofumarate based on Diels-Alder strategy. 1a and 1b inhibited protein kinase C at the IC_<50> values of 2×10^<-5>M and 1×10^<-5>M, respectively, but not protein kinase A at a concentration of 1×10^<-3>M. The structure-activity relationships are discussed.
- 公益社団法人日本薬学会の論文
- 1991-02-25
著者
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岩崎 為雄
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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西谷 喬
Research Laboratories of Tanabe Seiyaku Co., Ltd.,
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山崎 裕義
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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佐藤 忠司
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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佐藤 忠司
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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西谷 喬
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
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岩崎 為雄
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
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山崎 裕義
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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