A Facile Synthesis of Opically Pure Amines by Reduction of N-Acyl-α-methoyalkylamines Derived from α-Amino Acids Using Triethylsilane

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概要

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• Optically pure amines were synthesized effectively by Lewis acid-catalyzed triethylsilane reduction of N-acyl-α-methoxyalkylamines which were readily obtained by anodic oxidation of N-acyl-α-amino acids. This method was also applied to the conversion of an N-acylpeptide into the corresponding optically pure amine derivative.

• 社団法人日本薬学会の論文
• 1990-07-25

著者

• 西谷 喬

  Research Laboratories of Tanabe Seiyaku Co., Ltd.,

• 山崎 裕義

  Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,

• 堀川 袷志

  田辺製薬・拓新研

• 岩崎 為雄

  田辺製薬・拓新研

• 山崎 裕義

  Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co.,

• 堀川 袷志

  Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co.,

• 西谷 喬

  Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co.,

• 岩崎 為雄

  Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co.,

• 西谷 喬

  Research Laboratories Of Tanabe Seiyaku Co. Ltd.

• 山崎 裕義

  Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.

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