Synthesis of 3-Amino-3-(5-fluorouracil-1-yl) propionic Acid and 4-Amino-4-(5-fluorouracil-1-yl) butyric Acid Derivatives
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概要
- 論文の詳細を見る
3-Acylamino-3-(5-fluorouracil-1-yl) propionates (3a, b) and 4-acylamino-4-(5-fluoro-uracil-1-yl) butyrates (3c-e) were synthesized from 3-acylamino-3-carboxypropionates (1a, b) and 4-acylamino-4-carboxybutyrates (1c-e), respectively, via electrochemical oxidation. Catalytic hydrogenolysis of the benzyl esters (3a, c, d) gave the corresponding carboxylic acids (4a', c', d') without cleavage of the geminal diamine moieties.
- 公益社団法人日本薬学会の論文
- 1980-04-25
著者
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西谷 喬
Research Laboratories of Tanabe Seiyaku Co., Ltd.,
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西谷 喬
Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co.,
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岩崎 為雄
Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co.,
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西谷 喬
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
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岩崎 為雄
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
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井上 一三
Department Of Synthetic Chemistry Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd
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三好 宗次
Department Of Synthetic Chemistry Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd
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虫鹿 好孝
Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co.,
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虫鹿 好孝
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd
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