Studies on biologically Active Haloganenated Compounds. III. Synthesis and Antibacterial Activity of 7-Fluoromethyl-1,8-naphthyridine and Quinoline Derivatives
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概要
- 論文の詳細を見る
Some novel compounds having a fluoromethyl group at the C_7-position on 1-alkyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid and on 1-alkyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid were prepared and their antibacterial activities were examined in vitro. In a series of quinolines, no striking difference of antibacterial activities between the 7-fluoromethyl and 7-methyl derivatives was observed. However, the activity was increased in the series of 1,8-naphthyridines by replacement of the methyl group with the fluoromethyl group. As regards the N_1-substituents, the 2-fluoroethyl compound showed a higher activity than the others.
- 公益社団法人日本薬学会の論文
- 1982-10-25
著者
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谷 醇一
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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虫鹿 好孝
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd
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山口 東太郎
Microbiological Research Laboratory Tanabe Seiyaku Co. Ltd
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