Further Studies on Synthesis and Antimicrobial Activity of Thioformin Analogues
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概要
- 論文の詳細を見る
N-Substituted N-thioformylhydroxylamine derivatives represented by the general formula [chemical formula] (I) were synthesized and examined for antimicrobial activities. The synthesis was performed by the replacement of the carbonyl in an appropriate N-sub-stituted N-formylhydroxylamine with sulfur. These compounds were analogues of an antibiotic thioformin (II), N-methyl N-thioformylhydroxylamine, which was isolated as cupric complex (antibiotic YC-73 (III)) from a culture filtrate of Pseudomonas sp. The derivatives synthesized showed broad antimicrobial activities in vitro similar to that of the original antibiotic, particularly against gram-positive bacteria.
- 公益社団法人日本薬学会の論文
- 1974-10-25
著者
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海野 喜美夫
Microbial Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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山口 東太郎
Microbiological Research Laboratory Tanabe Seiyaku Co. Ltd
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宮城島 利一
Microbial Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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宮城島 利一
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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