Structure-Activity Correlations for N-Substituted N-Thioformyl-hydroxylamines on Bacterial Cells

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概要

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• The quantitative correlations between the chemical structure and the antibacterial activity against Staphylococcus aureus 209P, Bacillus subtilis PCI-219,Escherichia coli NIHJ and Salmonella typhimurium of 19 N-substituted N-thioformylhydroxylamine derivatives have been studied by Hansch-Fujita's method. These compounds are analogues of an antibiotic thioformin, N-methyl N-thioformylhydroxylamine. The following parameters were used in this study ; Hansch's π and chromatographic Rm values as hydrophobic parameters and pK_a value as an electronic parameter. As the result, in the N-substituted N-thioformylhydroxylamine series, the hydrophobic character of the molecule as expressed by π or Rm is closely correlated to the antibacterial activity of these compounds.

• 公益社団法人日本薬学会の論文
• 1974-10-25

著者

• 宮城島 利一

  Microbial Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.

• 宮城島 利一

  Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.,

関連論文

• Selective β_1-Adrenoceptor Agonist Activity of Denopamine and Its Derivatives in Dogs
• Further Studies on Synthesis and Antimicrobial Activity of Thioformin Analogues
• Structure-Activity Correlations for N-Substituted N-Thioformyl-hydroxylamines on Bacterial Cells

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