Synthetic Studies on Phosphorylating Reagent. III. Selective Phosphorylation of Unprotected Nucleoside by Means of 2-(N, N-Dimethylamino)-4-nitrophenyl Phosphate
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of 2-(N, N-dimethylamino)-4-nitrophenyl phosphate (1), a new phosphorylating agent, with the alcohol involving primary and secondary hydroxyl groups led to selective phosphorylation of the primary hydroxyl group. Thus, 1,2-propanediol and glycerol were phosphorylated to give exclusively the corresponding 1-phosphates. When unprotected nucleosides were treated with this reagent 1,nucleoside 5'-phosphates were obtained in satisfactory yield by simple work up.
- 公益社団法人日本薬学会の論文
- 1975-07-25
著者
-
田口 善彦
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
-
虫鹿 好孝
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
-
虫鹿 好孝
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd
関連論文
- Synthetic Studies on Phosphorylating Reagent. III. Selective Phosphorylation of Unprotected Nucleoside by Means of 2-(N, N-Dimethylamino)-4-nitrophenyl Phosphate
- Synthesis of 3-Amino-3-(5-fluorouracil-1-yl) propionic Acid and 4-Amino-4-(5-fluorouracil-1-yl) butyric Acid Derivatives
- Studies on biologically Active Halogenated Compounds. IV. Synthesis and Antibacterial Activity of Fluorinated Quinoline Derivatives
- Studies on biologically Active Haloganenated Compounds. III. Synthesis and Antibacterial Activity of 7-Fluoromethyl-1,8-naphthyridine and Quinoline Derivatives